Ticrynafen

• Catalog No.: DB04831
• CAS Number: 40180-04-9
• M. F.: C13H8Cl2O4S
• M. W.: 331.17122

SYNONYMS

• IUPAC name: 2-[2,3-dichloro-4-(thiophene-2-carbonyl)phenoxy]acetic acid
• IUPAC Traditional name: 2,3-dichloro-4-(thiophene-2-carbonyl)phenoxyacetic acid
• Brand Name: Diflurex; Selacryn; Ticrex
• Synonyms: 4-(2-Thienylketo)-2,3-dichlorophenoxyacetic acid; Acide tienilique [inn-french]; (2,3-Dichloro-4-(2-thiophenecarbonyl)phenoxy)acetic acid; Thienylic acid; Tienilic acid; (2,3-Dichloro-4-(2-thenoyl)phenoxy)acetic acid; 4-(2-Theonyl)-2,3-dichlorphenoxyessigsaeure [German]; (2,3-Dichloro-4-(2-thienylcarbonyl)phenoxy)acetic acid; Acidum tienilicum [inn-latin]; Acido tienilico [inn-spanish]; Tienilico acido [spanish]

DATABASE IDS

• CAS Number: 40180-04-9
• PubChem SID: 46505485
• PubChem CID: 38409

DETAILS

Description (English)

• Drug Groups: withdrawn
• Description: Ticrynafen, or tienilic acid, is a diuretic drug with uric acid-lowering (uricosuric) action, formerly marketed for the treatment of hypertension. It was withdrawn in 1982, shortly after its introduction to the market, after case reports in the United States indicated a link between the use of ticrynafen and hepatitis. (Manier et al., 1982)
• Indication: For the treatment of hypertension.
• Affected Organisms: Humans and other mammals
• References: Manier JW, Chang WW, Kirchner JP, Beltaos E: Hepatotoxicity associated with ticrynafen--a uricosuric diuretic. Am J Gastroenterol. 1982 Jun;77(6):401-4. [Pubmed]
• External Links: Wikipedia

REFERENCES

• Manier JW, Chang WW, Kirchner JP, Beltaos E: Hepatotoxicity associated with ticrynafen--a uricosuric diuretic. Am J Gastroenterol. 1982 Jun;77(6):401-4. Pubmed