Buformin

• Catalog No.: DB04830
• CAS Number: 692-13-7
• M. F.: C6H15N5
• M. W.: 157.2168

SYNONYMS

• IUPAC name: (E)-2-butyl-1-(diaminomethylidene)guanidine
• IUPAC Traditional name: buformin
• Brand Name: Panformin; Andere; Diabrin; Glybigidum; Sindiatil; Adebit; Biforon; Glybigid; Silubin
• Synonyms: Butformin; 1-Butylbiguanide; Butylbiguanide; Buforminum [inn-latin]; 1-Butyldiguanide; Buformina [inn-spanish]; Buformine HCL; Butyl guanylguanidine; Butylbiguanidum; DBV; DBV hydrochloride; N-butylbiguanide; Buformin hydrochloride; Buformine; Buformine [inn-french]; Butylbiguanide hydrochloride; Butyldiguanide

DATABASE IDS

• CAS Number: 692-13-7
• PubChem CID: 2468
• PubChem SID: 46507254

PROPERTIES

• Hydrophobicity(logP): -1.20 [HANSCH,C ET AL. (1995)]

DETAILS

Description (English)

• Drug Groups: withdrawn
• Description: Buformin is an anti-diabetic drug of the biguanide class, chemically related to metformin and phenformin. It was withdrawn from the market in most countries due to a high risk of causing lactic acidosis.
• Affected Organisms: Humans and other mammals
• References: Verdonck LF, Sangster B, van Heijst AN, de Groot G, Maes RA: Buformin concentrations in a case of fatal lactic acidosis. Diabetologia. 1981;20(1):45-6. [Pubmed] ; Deppermann D, Heidland A, Ritz E, Horl W: [Lactic acidosis--a possible complication in buformin-treated diabetics (author's transl)] Klin Wochenschr. 1978 Sep 1;56(17):843-53. [Pubmed]
• External Links: Wikipedia

REFERENCES

• Verdonck LF, Sangster B, van Heijst AN, de Groot G, Maes RA: Buformin concentrations in a case of fatal lactic acidosis. Diabetologia. 1981;20(1):45-6. Pubmed
• Deppermann D, Heidland A, Ritz E, Horl W: [Lactic acidosis--a possible complication in buformin-treated diabetics (author's transl)] Klin Wochenschr. 1978 Sep 1;56(17):843-53. Pubmed