Lysergic Acid Diethylamide

• Catalog No.: DB04829
• CAS Number: 50-37-3
• M. F.: C20H25N3O
• M. W.: 323.432

SYNONYMS

• IUPAC name: (4R,7R)-N,N-diethyl-6-methyl-6,11-diazatetracyclo[7.6.1.0^{2,7}.0^{12,16}]hexadeca-1(16),2,9,12,14-pentaene-4-carboxamide
• IUPAC Traditional name: lysergic acid diethylamide
• Synonyms: Blotter acid; Lysergide; Orange sunshine; N,n-diethyllysergamide; Brown dots; n,n-diethyl-(+)-lysergamide; Lysergidum [inn-latin]; Delysid; D-lysergic acid diethylamide; Cubes; Mellow yellow; Lysergic acid amide; Lysergamid; Frogs; Domes; LSD-25; Paper acid; N,n-diethyl-d-lysergamide; D-lysergic acid n,n-diethylamide; D-LSD-25; D-LSD; Cupcakes; Coffeinum; Lysergaure diethylamid; Lysergamide; Lucy in the sky with diamonds; Heavenly blue; Gelatin chips; (+)-LSD; 9,10-Didehydro-N,N-diethyl-6-methylergoline-8b-carboxamide; Bart simpson; Big f; Blue cheer; Wedges; Wedding bells; Trippers; TMA; The hawk; Sunshine; Sugar; Strawberry fields; Spoonies; N,N-Diethyl-6-methyl-9,10-didehydroergoline-8-carboxamide; Diethylamid kyseliny lysergove [czech]; Dextrolysergic acid diethylamide; D-lysergic acid dethylamide; Contact lens; Clearlight; Chocolate chips; Chief; Cherry top; California sunshine; Blue star; Blue mist; Microdots; Mean green; Lysergic acid diethylamide-25; Greenies; Flats; Fifty; Ergine; LSD; (+)-lysergic acid diethylamide; Acid; Barrels; Bartman; Beast; Blue acid; ZEN; Yellows; Window pane; White light; Ubergluben; TABS; Sugar lump; Scapes; Royal blue; Purple microdot; Purple haze; Pearly gates; Owsley; Orange wedges; Orange mushroom

DATABASE IDS

• PubChem SID: 46506397
• PubChem CID: 5761
• CAS Number: 50-37-3

PROPERTIES

• Hydrophobicity(logP): 2.95 [HANSCH,C ET AL. (1995)]

DETAILS

Description (English)

• Drug Groups: illicit; withdrawn
• Description: Debate continues over the nature and causes of chronic flashbacks. Explanations in terms of LSD physically remaining in the body for months or years after consumption have been discounted by experimental evidence. Some say HPPD is a manifestation of post-traumatic stress disorder, not related to the direct action of LSD on brain chemistry, and varies according to the susceptibility of the individual to the disorder. Many emotionally intense experiences can lead to flashbacks when a person is reminded acutely of the original experience. However, not all published case reports of chronic flashbacks appear to describe an anxious hyper-vigilant state reminiscent of post-traumatic stress disorder.
• Toxicity: Estimates for the lethal dosage (LD50) of LSD range from 200 μg/kg to more than 1 mg/kg of human body mass, though most sources report that there are no known human cases of such an overdose.
• Affected Organisms: Humans and other mammals
• Biotransformation: Hepatic.
• Half Life: 3 hours
• References: GREINER T, BURCH NR, EDELBERG R: Psychopathology and psychophysiology of minimal LSD-25 dosage; a preliminary dosage-response spectrum. AMA Arch Neurol Psychiatry. 1958 Feb;79(2):208-10. [Pubmed] ; AGHAJANIAN GK, BING OH: PERSISTENCE OF LYSERGIC ACID DIETHYLAMIDE IN THE PLASMA OF HUMAN SUBJECTS. Clin Pharmacol Ther. 1964 Sep-Oct;5:611-4. [Pubmed] ; Papac DI, Foltz RL: Measurement of lysergic acid diethylamide (LSD) in human plasma by gas chromatography/negative ion chemical ionization mass spectrometry. J Anal Toxicol. 1990 May-Jun;14(3):189-90. [Pubmed] ; Nichols DE: Hallucinogens. Pharmacol Ther. 2004 Feb;101(2):131-81. [Pubmed] ; Jacobs BL, Heym J, Rasmussen K: Raphe neurons: firing rate correlates with size of drug response. Eur J Pharmacol. 1983 Jun 3;90(2-3):275-8. [Pubmed]
• External Links: Wikipedia

REFERENCES

• GREINER T, BURCH NR, EDELBERG R: Psychopathology and psychophysiology of minimal LSD-25 dosage; a preliminary dosage-response spectrum. AMA Arch Neurol Psychiatry. 1958 Feb;79(2):208-10. Pubmed
• AGHAJANIAN GK, BING OH: PERSISTENCE OF LYSERGIC ACID DIETHYLAMIDE IN THE PLASMA OF HUMAN SUBJECTS. Clin Pharmacol Ther. 1964 Sep-Oct;5:611-4. Pubmed
• Papac DI, Foltz RL: Measurement of lysergic acid diethylamide (LSD) in human plasma by gas chromatography/negative ion chemical ionization mass spectrometry. J Anal Toxicol. 1990 May-Jun;14(3):189-90. Pubmed
• Jacobs BL, Heym J, Rasmussen K: Raphe neurons: firing rate correlates with size of drug response. Eur J Pharmacol. 1983 Jun 3;90(2-3):275-8. Pubmed
• Nichols DE: Hallucinogens. Pharmacol Ther. 2004 Feb;101(2):131-81. Pubmed