Nialamide

• Catalog No.: DB04820
• CAS Number: 51-12-7
• M. F.: C16H18N4O2
• M. W.: 298.33972

SYNONYMS

• IUPAC name: N-benzyl-3-(pyridin-4-ylformohydrazido)propanamide
• IUPAC Traditional name: nialamide
• Brand Name: NF-xIII; Espril; Mygal; Niamid; Delmoneurina; Isalizina; Nialamid; Niamidal; Niamide; Niaquitil; Niazin; Nuredal; Nyazin; Nyezin; Psicodisten; Surgex; Novazid
• Synonyms: N-isonicotinoyl-n'(beta-n-benzylcarboxamidoethyl)hydrazine; 1-[2-(Benzylcarbamoyl)ethyl]-2-isonicotinoylhydrazine; 2-(2-(Benzylcarbamoyl)ethyl)hydrazide isonicotinic acid; 1-(2-(Benzylcarbamoyl)ethyl)-2-isonicotinoylhydrazine; 2-[2-(Benzylcarbamoyl)ethyl]hydrazide isonicotinic acid; Isonicotinic acid, 2-(2-(benzylcarbamoyl)ethyl)hydrazide; Isonicotinic acid, 2-[2-(benzylcarbamoyl)ethyl]hydrazide; Lopac-N-1392; N-(2-(Benzylcarbamyl)ethylamino)isonicotinamide; N-Benzyl-3-(2-isonicotinoylhydrazino)propanamide; Nialamidum [inn-latin]; Pyridine-4-carboxylic 2-[2-(benzylcarbamoyl)ethyl]hydrazide; 2-(2-(Benzylcarbamoyl)ethyl)hydrazide, isonicotinic acid; 2-(2-(Benzylcarbamyl)ethyl)hydrazide isonicotinic acid; BEIH; Isonicitinic acid 2-[(2-benzylcarbamoyl)ethyl]hydrazide; Isonicotinic acid 2-((2-benzylcarbamoyl)ethyl)hydrazide; Isonicotinic acid, 2-[2- (benzylcarbamoyl)ethyl]hydrazide; Isonicotinic acid, 2-[2-(benzylcarbamoylethyl]hydrazide; Isonicotinic acid, {2-[2-(benzylcarbamoyl)ethyl]hydrazide}; Isonicotinic acid, {2-[2-(benzylcarbamoylethyl]hydrazide}; N-benzyl-beta-(isonicotinoylhydrazine)propionamide; N-isonicotinyl hydrazide; N-benzyl-beta-(isonicotinylhydrazino)propionamide; Nialamida [inn-spanish]

DATABASE IDS

• PubChem SID: 46506047
• PubChem CID: 4472
• CAS Number: 51-12-7

PROPERTIES

• Hydrophobicity(logP): 0.87 [HANSCH,C ET AL. (1995)]

DETAILS

Description (English)

• Drug Groups: withdrawn
• Description: Withdrawn from the Canadian, US, and UK markets in 1963 due to interactions with food products containing tyrosine.
• Affected Organisms: Humans and other mammals
• References: Benady DR, Clein LJ, Pare CM: Intramuscular nialamide in intractable depression. Dis Nerv Syst. 1965 Dec;26(12):792-4. [Pubmed] ; OULES J, CAZABON: [TREATMENT OF DEPRESSIVE STATES WITH INTRAVENOUS NIAMIDE.] Toulouse Med. 1964 Dec;65:1298-302. [Pubmed] ; VAISBERG M, McGAHEE CL, RADINGER N, SAUNDERS JC: Nialamide for the treatment of anergy and depression. Dis Nerv Syst. 1959 Aug;20(Suppl):22-5. [Pubmed]
• External Links: Wikipedia

REFERENCES

• Benady DR, Clein LJ, Pare CM: Intramuscular nialamide in intractable depression. Dis Nerv Syst. 1965 Dec;26(12):792-4. Pubmed
• OULES J, CAZABON: [TREATMENT OF DEPRESSIVE STATES WITH INTRAVENOUS NIAMIDE.] Toulouse Med. 1964 Dec;65:1298-302. Pubmed
• VAISBERG M, McGAHEE CL, RADINGER N, SAUNDERS JC: Nialamide for the treatment of anergy and depression. Dis Nerv Syst. 1959 Aug;20(Suppl):22-5. Pubmed