19-nor-14-epi-23-yne-1,25 dihydroxyvitamin D3

• Catalog No.: DB04796
• M. F.: C27H40O3
• M. W.: 412.6047

SYNONYMS

• IUPAC name: (1R,3S,5Z)-5-{2-[(1R,3aR,4Z,7aR)-1-[(2R)-6-hydroxy-6-methylhept-4-yn-2-yl]-7a-methyl-octahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol
• IUPAC Traditional name: (1R,3S,5Z)-5-{2-[(1R,3aR,4Z,7aR)-1-[(2R)-6-hydroxy-6-methylhept-4-yn-2-yl]-7a-methyl-hexahydro-1H-inden-4-ylidene]ethylidene}-4-methylidenecyclohexane-1,3-diol
• Synonyms: TX522

DATABASE IDS

• PubChem CID: 46937021
• PubChem SID: 46504586

DETAILS

Description (English)

• Drug Groups: experimental
• Indication: Investigated for use/treatment in prostate cancer, psoriasis and hyperparathyroidism.
• References: Wong MS, Delansorne R, Man RY, Vanhoutte PM: Vitamin D derivatives acutely reduces endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol. 2008 May 16;. [Pubmed] ; Eelen G, Verlinden L, Van Camp M, Claessens F, De Clercq P, Vandewalle M, Bouillon R, Verstuyf A: Altered Vitamin D receptor-coactivator interactions reflect superagonism of Vitamin D analogs. J Steroid Biochem Mol Biol. 2005 Oct;97(1-2):65-8. Epub 2005 Jul 20. [Pubmed] ; Company Website [Link]

REFERENCES

• Wong MS, Delansorne R, Man RY, Vanhoutte PM: Vitamin D derivatives acutely reduces endothelium-dependent contractions in the aorta of the spontaneously hypertensive rat. Am J Physiol Heart Circ Physiol. 2008 May 16;. Pubmed
• Eelen G, Verlinden L, Van Camp M, Claessens F, De Clercq P, Vandewalle M, Bouillon R, Verstuyf A: Altered Vitamin D receptor-coactivator interactions reflect superagonism of Vitamin D analogs. J Steroid Biochem Mol Biol. 2005 Oct;97(1-2):65-8. Epub 2005 Jul 20. Pubmed
• Company Website Link