Suramin

• Catalog No.: DB04786
• CAS Number: 145-63-1
• M. F.: C51H40N6O23S6
• M. W.: 1297.2797

SYNONYMS

• IUPAC name: 8-{4-methyl-3-[3-({[3-({2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl}carbamoyl)phenyl]carbamoyl}amino)benzamido]benzamido}naphthalene-1,3,5-trisulfonic acid
• IUPAC Traditional name: 8-{4-methyl-3-[3-({[3-({2-methyl-5-[(4,6,8-trisulfonaphthalen-1-yl)carbamoyl]phenyl}carbamoyl)phenyl]carbamoyl}amino)benzamido]benzamido}naphthalene-1,3,5-trisulfonic acid
• Brand Name: Naganil; Germanin; Naganol; Antrypol; Fourneau; Farma; Belganyl; Moranyl; Naganin; Naphuride; Naganine
• Synonyms: Suramine; Bayer 205; Sodium suramin; Suramin sodium; Suramine sodium; SVR

DATABASE IDS

• PubChem SID: 46507013
• PubChem CID: 5361
• CAS Number: 145-63-1

DETAILS

Description (English)

• Drug Groups: approved
• Description: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties. Suramin is manufactured by Bayer in Germany as Germanin?.
• Indication: For treatment of human sleeping sickness, onchocerciasis and other diseases caused by trypanosomes and worms.
• Affected Organisms: Yeast, Molds, Trypanosomes
• Biotransformation: Little or no metabolism
• Absorption: Poorly absorbed from the gastrointestinal tract.
• Half Life: Approximately 36 to 60 days
• Protein Binding: Approximately 99.7%
• External Links: Wikipedia