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Iodipamide

Catalog No. DB04711 Name DrugBank
CAS Number 606-17-7 Website http://www.ualberta.ca/
M. F. C20H14I6N2O6 Telephone (780) 492-3111
M. W. 1139.76178 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 4263

SYNONYMS

IUPAC name
3-{5-[(3-carboxy-2,4,6-triiodophenyl)carbamoyl]pentanamido}-2,4,6-triiodobenzoic acid
IUPAC Traditional name
iodipamide
Brand Name
Bilignost
Cholografin
Biligrafin
Transbilix
Cholospect
Bilignostum
Synonyms
Adipiodonum [INN-Latin]
3,3'-[(1,6-dioxohexane-1,6-diyl)diimino]bis(2,4,6-triiodobenzoic acid)
Iodipamic acid
Adipiodone
Adipiodona [INN-Spanish]
IDB

DATABASE IDS

PubChem SID 46507320
CAS Number 606-17-7
PubChem CID 3739

PROPERTIES

Solubility 0.46 mg/mL at 20 oC [BEILSTEIN]

DETAILS

Description (English)
Item Information
Drug Groups approved
Description Iodipamide is a water-soluble radiographic contrast media for cholecystography and intravenous cholangiography. [PubChem]
Indication Iodipamide is used as a contrast agent for cholecystography and intravenous cholangiography.
Toxicity Ionic radiocontrast agents like iodipamide are cytotoxic to renal cells. The toxic effects include apoptosis, cellular energy failure, disruption of calcium homeostasis, and disturbance of tubular cell polarity, and are thought to be linked to oxidative stress. Acute IV LD50 is 5000 mg/kg in rat, 3195 mg/kg in mouse, and 1200 mg/kg in dog.

Affected Organisms
Humans and other mammals
Biotransformation Hepatic.
References
Lin SK, Moss AA, Riegelman S: Iodipamide kinetics: capacity-limited biliary excretion with simultaneous pseudo-first-order renal excretion. J Pharm Sci. 1977 Dec;66(12):1670-4. [Pubmed]

REFERENCES

  • Lin SK, Moss AA, Riegelman S: Iodipamide kinetics: capacity-limited biliary excretion with simultaneous pseudo-first-order renal excretion. J Pharm Sci. 1977 Dec;66(12):1670-4. Pubmed