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Methoxsalen

Catalog No. DB00553 Name DrugBank
CAS Number 298-81-7 Website http://www.ualberta.ca/
M. F. C12H8O4 Telephone (780) 492-3111
M. W. 216.18952 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 435

SYNONYMS

IUPAC name
9-methoxy-7H-furo[3,2-g]chromen-7-one
IUPAC Traditional name
methoxsalen
Brand Name
New-Meladinin
Ammoidin
Zanthotoxin
Oxsoralen-Ultra
Meladinine
Ammodin
Meladinin
Meloxine
Methoxaten
Oxsoralen
Proralone-Mop
Puvamet
Ultra Mop
Ultramop Lotion
Uvadex
Meladoxen
Methoxa-Dome
Methoxalen
Oxoralen
Oxsoralen Lotion
Oxypsoralen
Psoralen-Mop
Puvalen
Xanthotoxin
Xanthotoxine
Xanthoxin

DATABASE IDS

PubChem CID 4114
CAS Number 298-81-7
PubChem SID 46506275

PROPERTIES

Hydrophobicity(logP) 1.7
Solubility 0.0476 mg/mL at 30 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

DETAILS

Description (English)
Item Information
Drug Groups approved
Description A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. [PubChem]
Indication For the treatment of psoriasis and vitiligo
Pharmacology Methoxsalen selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Methoxsalen-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
Affected Organisms
Humans and other mammals
Half Life Approximately 2 hours
Elimination In both mice and man, methoxsalen is rapidly metabolized. Approximately 95% of the drug is excreted as a series of metabolites in the urine within 24 hours (Pathak et al. 1977).
External Links
Wikipedia
RxList
Drugs.com

REFERENCES