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Acetohydroxamic Acid

Catalog No. DB00551 Name DrugBank
CAS Number 546-88-3 Website http://www.ualberta.ca/
M. F. C2H5NO2 Telephone (780) 492-3111
M. W. 75.0666 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 433

SYNONYMS

IUPAC name
N-hydroxyacetamide
IUPAC Traditional name
acetohydroxamic acid
Brand Name
Lithostat
Synonyms
Acetyl hydroxyamino
Acethydroxamsaure
AHA
N-Hydroxyacetamide
Cetohyroxamic acid
Methylhydroxamic acid
Acetylhydroxamic acid
Acetohydroximic acid
Acetic acid, oxime
Acetohydroxamate

DATABASE IDS

PubChem CID 1990
PubChem SID 46508546
CAS Number 546-88-3

PROPERTIES

Hydrophobicity(logP) -0.7
Solubility 1E+006 mg/L

DETAILS

Description (English)
Item Information
Drug Groups approved
Description Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. It is used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections.
Indication Used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections.
Pharmacology Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly.
Toxicity Oral, rat: LD50 = 4.8gm/kg. Symptoms of overdose include anorexia, malaise, lethargy, diminished sense of wellbeing, tremor, anxiety, nausea, and vomiting.
Affected Organisms
Enteric bacteria and other eubacteria
Biotransformation 35-65% of oral dose excreted unchanged in urine (which provides the drug's therapeutic effect).
Absorption Well absorbed from the GI tract following oral administration.
Half Life 5-10 hours in patients with normal renal function
Protein Binding No known binding
References
[Link]
External Links
Wikipedia
Drugs.com

REFERENCES