| Item |
Information |
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Drug Groups
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approved |
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Description
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Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. It is used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections. |
| Indication |
Used, in addition to antibiotics or medical procedures, to treat chronic urea-splitting urinary infections. |
| Pharmacology |
Acetohydroxamic Acid, a synthetic drug derived from hydroxylamine and ethyl acetate, is similar in structure to urea. In the urine, it acts as an antagonist of the bacterial enzyme urease. Acetohydroxamic Acid has no direct antimicrobial action and does not acidify urine directly. |
| Toxicity |
Oral, rat: LD50 = 4.8gm/kg. Symptoms of overdose include anorexia, malaise, lethargy, diminished sense of wellbeing, tremor, anxiety, nausea, and vomiting. |
| Affected Organisms |
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Enteric bacteria and other eubacteria |
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| Biotransformation |
35-65% of oral dose excreted unchanged in urine (which provides the drug's therapeutic effect). |
| Absorption |
Well absorbed from the GI tract following oral administration. |
| Half Life |
5-10 hours in patients with normal renal function |
| Protein Binding |
No known binding |
| References |
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| External Links |
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