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Aldosterone

Catalog No. DB04630 Name DrugBank
CAS Number 52-39-1 Website http://www.ualberta.ca/
M. F. C21H28O5 Telephone (780) 492-3111
M. W. 360.44402 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 4191

SYNONYMS

IUPAC name
(1S,2R,10S,11S,14S,15R,17S)-17-hydroxy-14-(2-hydroxyacetyl)-2-methyl-5-oxotetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadec-6-ene-15-carbaldehyde
IUPAC Traditional name
aldosterone
Synonyms
11beta,21-Dihydroxy-3,20-diketo-4-pregnen-18-al
Aldocortene
Elektrocortin
Aldosterona [inn-spanish]
(+)-aldosterone
11beta,21-Dihydroxy-3,20-diketopregn-4-ene-18-al
11beta,21-Dihydroxypregn-4-ene-3,18,20-trione
11beta,21-dihydroxy-3,20-dioxo-pregn-4-ene-18-al
11beta,21-dihydroxy-3,20-dioxopregn-4-en-18-al
18-Aldocorticosterone
18-Formyl-11beta,21-dihydroxy-4-pregnene-3,20-dione
Aldocortin
Aldosteronum [inn-latin]
D-aldosterone
Electrocortin
11beta,21-dihydroxy-3,20-dioxo-4-pregnen-18-al
18-Oxocorticosterone
Aldocorten

DATABASE IDS

PubChem CID 5839
PubChem SID 46505770
CAS Number 52-39-1

PROPERTIES

Hydrophobicity(logP) 1.08 [HANSCH,C ET AL. (1995)]
Solubility 0.0512 mg/mL at 37 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]

DETAILS

Description (English)
Item Information
Drug Groups experimental
Description A hormone secreted by the adrenal cortex that regulates electrolyte and water balance by increasing the renal retention of sodium and the excretion of potassium. [PubChem]
Pharmacology At the late distal tubule and collecting duct, aldosterone has two main actions: 1) aldosterone acts on mineralocorticoid receptors (MR) on principal cells in the distal tubule of the kidney nephron, increasing the permeability of their apical (luminal) membrane to potassium and sodium and activates their basolateral Na+/K+ pumps, stimulating ATP hydrolysis leading to phosphorylation of the pump and a conformational change in the pump exposes the Na+ ions to the outside. The phosphorylated form of the pump has a low affinity for Na+ ions, hence reabsorbing sodium (Na+) ions and water into the blood, and secreting potassium (K+) ions into the urine; 2) aldosterone stimulates H+ secretion by intercalated cells in the collecting duct, regulating plasma bicarbonate (HCO3?) levels and its acid/base balance; and 3) aldosterone may act on the central nervous system via the posterior pituitary gland to release vasopressin (ADH) which serves to conserve water by direct actions on renal tubular resorption.
Affected Organisms
Humans and other mammals
References
Williams JS, Williams GH: 50th anniversary of aldosterone. J Clin Endocrinol Metab. 2003 Jun;88(6):2364-72. [Pubmed]
External Links
Wikipedia

REFERENCES

  • Williams JS, Williams GH: 50th anniversary of aldosterone. J Clin Endocrinol Metab. 2003 Jun;88(6):2364-72. Pubmed