Cycloleucine

• Catalog No.: DB04620
• CAS Number: 52-52-8
• M. F.: C6H11NO2
• M. W.: 129.15704

SYNONYMS

• IUPAC name: 1-aminocyclopentane-1-carboxylic acid
• IUPAC Traditional name: cycloleucine
• Synonyms: ACP; 1-Amino-1-cyclopentanecarboxylic acid; 1-Aminocyclopentanecarboxylate; Amino-1-cyclopentanecarboxylic acid; 1-Aminocyclopentanecarboxylic acid; Cyclo-leucine; Cycloleucin; 1-Amino-cyclopentanecarboxylic acid; 1-Aminocyclopentane-1-carboxylic acid; ACPC

DATABASE IDS

• PubChem SID: 46505671
• PubChem CID: 2901
• CAS Number: 52-52-8

PROPERTIES

• Hydrophobicity(logP): -2.28 [TSAI,RS ET AL. (1991)]
• Solubility: 50 mg/mL at 25 oC [MERCK INDEX (1996)]

DETAILS

Description (English)

• Drug Groups: experimental
• Description: Cycloleucine is an amino acid formed by cyclization of leucine. Cycloleucine is a non-metabolisable amino acid and is a specific and reversible inhibitor of nucleic acid methylation, and as such is widely used in biochemical experiments. [Wikipedia]
• Pharmacology: Cycloleucine has cytostatic, immunosuppressive and antineoplastic activities.
• Toxicity: Oral, mouse: LD₅₀ = 309 mg/kg; oral, rat: LD₅₀ = 290 mg/kg
• Affected Organisms: Humans and other mammals
• References: Herberg LJ, Rose IC: Effects of D-cycloserine and cycloleucine, ligands for the NMDA-associated strychnine-insensitive glycine site, on brain-stimulation reward and spontaneous locomotion. Pharmacol Biochem Behav. 1990 Aug;36(4):735-8. [Pubmed]
• External Links: Wikipedia

REFERENCES

• Herberg LJ, Rose IC: Effects of D-cycloserine and cycloleucine, ligands for the NMDA-associated strychnine-insensitive glycine site, on brain-stimulation reward and spontaneous locomotion. Pharmacol Biochem Behav. 1990 Aug;36(4):735-8. Pubmed