| Item |
Information |
|
Drug Groups
|
approved |
|
Description
|
The 3-cyclopentyl ether of ethinyl estradiol. |
| Indication |
Used in hormone replacement therapy, treating symptoms of menopause such as hot flashes. Also used to treat breast and prostate cancer. |
| Pharmacology |
Quinestrol is the 3-cyclopentyl ether of ethinyl estradiol (the active metabolite). After gastrointestinal absorption, it is stored in adipose tissue where it is slowly released and metabolized principally to the parent compound, ethinyl estradiol. Ethinyl estradiol is a synthetic derivative of the natural estrogen estradiol. |
| Toxicity |
Symptoms of overdose include nausea and vomiting, and withdrawal bleeding may occur in females. |
| Affected Organisms |
| • |
Humans and other mammals |
|
| Biotransformation |
Metabolized principally to the parent compound, ethinyl estradiol. Ethinyl estradiol is metabolized in the liver. Quantitatively, the major metabolic pathway for ethinyl estradiol, both in rats and in humans, is aromatic hydroxylation, as it is for the natural estrogens. |
| Absorption |
Absorbed following oral administration. |
| External Links |
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