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Quinestrol

Catalog No. DB04575 Name DrugBank
CAS Number 152-43-2 Website http://www.ualberta.ca/
M. F. C25H32O2 Telephone (780) 492-3111
M. W. 364.52038 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 4143

SYNONYMS

IUPAC name
(1S,10R,11S,14R,15S)-5-(cyclopentyloxy)-14-ethynyl-15-methyltetracyclo[8.7.0.0^{2,7}.0^{11,15}]heptadeca-2(7),3,5-trien-14-ol
IUPAC Traditional name
quinestrol
Brand Name
Qui-lea
Estrovis
Estrovis 4000
Plestrovis
Estrovister
Eston
Synonyms
Quinestrolo [dcit]
17alpha-Ethynylestradiol 3-cyclopentyl ether
Estradiol-17-beta 3-cyclopentyl ether
Quinestrolum [inn-latin]
17-alpha-Ethinylestradiol 3-cyclopentyl ether

DATABASE IDS

PubChem CID 9046
PubChem SID 46508939
CAS Number 152-43-2

PROPERTIES

DETAILS

Description (English)
Item Information
Drug Groups approved
Description The 3-cyclopentyl ether of ethinyl estradiol.
Indication Used in hormone replacement therapy, treating symptoms of menopause such as hot flashes. Also used to treat breast and prostate cancer.
Pharmacology Quinestrol is the 3-cyclopentyl ether of ethinyl estradiol (the active metabolite). After gastrointestinal absorption, it is stored in adipose tissue where it is slowly released and metabolized principally to the parent compound, ethinyl estradiol. Ethinyl estradiol is a synthetic derivative of the natural estrogen estradiol.
Toxicity Symptoms of overdose include nausea and vomiting, and withdrawal bleeding may occur in females.
Affected Organisms
Humans and other mammals
Biotransformation Metabolized principally to the parent compound, ethinyl estradiol. Ethinyl estradiol is metabolized in the liver. Quantitatively, the major metabolic pathway for ethinyl estradiol, both in rats and in humans, is aromatic hydroxylation, as it is for the natural estrogens.
Absorption Absorbed following oral administration.
External Links
Wikipedia

REFERENCES