Alitretinoin

• Catalog No.: DB00523
• CAS Number: 5300-03-8
• M. F.: C20H28O2
• M. W.: 300.43512

SYNONYMS

• IUPAC name: (2E,4E,6Z,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
• IUPAC Traditional name: alitretinoin
• Brand Name: Panrexin; Renova; Panretyn; Retin-A; Panretin; Panretin Gel; Retin-A Micro; Vesanoid
• Synonyms: Retinoic Acid; ALRT-1057; BAL4079; alitretinoin; 9-cis-Retinoic acid

DATABASE IDS

• CAS Number: 5300-03-8

PROPERTIES

• Hydrophobicity(logP): 4.2
• Solubility: 0.6 mg/L

DETAILS

Description (English)

• Drug Groups: approved; investigational
• Description: An important regulator of gene expression during growth and development, and in neoplasms. Tretinoin, also known as retinoic acid and derived from maternal vitamin A, is essential for normal growth; and embryonic development. An excess of tretinoin can be teratogenic. It is used in the treatment of psoriasis; acne vulgaris; and several other skin diseases. It has also been approved for use in promyelocytic leukemia (leukemia, promyelocytic, acute). [PubChem]
• Indication: For topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma.
• Pharmacology: Alitretinoin (9-cis-retinoic acid) is a naturally-occurring endogenous retinoid indicated for topical treatment of cutaneous lesions in patients with AIDS-related Kaposi's sarcoma. Alitretinoin inhibits the growth of Kaposi's sarcoma (KS) cells in vitro.
• Affected Organisms: Humans and other mammals
• External Links: Wikipedia; RxList; Drugs.com