L-Histidine

• Catalog No.: DB00117
• CAS Number: 71-00-1
• M. F.: C6H9N3O2
• M. W.: 155.15456

SYNONYMS

• IUPAC name: (2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid
• IUPAC Traditional name: L-histidine
• Synonyms: L-(-)-Histidine; (S)-Histidine; Histidine; (S)-alpha-Amino-1H-imidazole-4-propionic acid; (S)-4-(2-Amino-2-carboxyethyl)imidazole; (S)-a-Amino-1H-imidazole-4-propanoic acid; Glyoxaline-5-alanine

DATABASE IDS

• PubChem SID: 46507001
• PubChem CID: 6274
• CAS Number: 71-00-1

PROPERTIES

• Hydrophobicity(logP): -3.4
• Solubility: Not AvailableSoluble

DETAILS

Description (English)

• Drug Groups: approved; nutraceutical
• Description: An essential amino acid that is required for the production of histamine. [PubChem]
• Indication: The actions of supplemental L-histidine are entirely unclear. It may have some immunomodulatory as well as antioxidant activity. L-histidine may be indicated for use in some with rheumatoid arthritis. It is not indicated for treatment of anemia or uremia or for lowering serum cholesterol.
• Pharmacology: Is found abundantly in hemoglobin; has been used in the treatment of rheumatoid arthritis, allergic diseases, ulcers and anemia. A deficiency can cause poor hearing.
• Toxicity: ORL-RAT LD₅₀ > 15000 mg/kg, IPR-RAT LD₅₀ > 8000 mg/kg, ORL-MUS LD₅₀ > 15000 mg/kg, IVN-MUS LD₅₀ > 2000 mg/kg; Mild gastrointestinal side effects.
• Affected Organisms: Humans and other mammals
• Absorption: Absorbed from the small intestine via an active transport mechanism requiring the presence of sodium.
• External Links: Wikipedia; PDRhealth