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L-Histidine_Molecular_structure_CAS_71-00-1)
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L-Histidine

Catalog No. DB00117 Name DrugBank
CAS Number 71-00-1 Website http://www.ualberta.ca/
M. F. C6H9N3O2 Telephone (780) 492-3111
M. W. 155.15456 Fax (780) 492-1071
Purity Email david.wishart@ualberta.ca
Storage Chembase ID: 4

SYNONYMS

IUPAC name
(2S)-2-amino-3-(1H-imidazol-5-yl)propanoic acid
IUPAC Traditional name
L-histidine
Synonyms
(S)-4-(2-Amino-2-carboxyethyl)imidazole
(S)-a-Amino-1H-imidazole-4-propanoic acid
(S)-alpha-Amino-1H-imidazole-4-propionic acid
(S)-Histidine
Glyoxaline-5-alanine
Histidine
L-(-)-Histidine

DATABASE IDS

CAS Number 71-00-1
PubChem CID 6274
PubChem SID 46507001

PROPERTIES

Hydrophobicity(logP) -3.4
Solubility Not AvailableSoluble

DETAILS

Description (English)
Item Information
Drug Groups approved; nutraceutical
Description An essential amino acid that is required for the production of histamine. [PubChem]
Indication The actions of supplemental L-histidine are entirely unclear. It may have some immunomodulatory as well as antioxidant activity. L-histidine may be indicated for use in some with rheumatoid arthritis. It is not indicated for treatment of anemia or uremia or for lowering serum cholesterol.
Pharmacology Is found abundantly in hemoglobin; has been used in the treatment of rheumatoid arthritis, allergic diseases, ulcers and anemia. A deficiency can cause poor hearing.
Toxicity ORL-RAT LD50 > 15000 mg/kg, IPR-RAT LD50 > 8000 mg/kg, ORL-MUS LD50 > 15000 mg/kg, IVN-MUS LD50 > 2000 mg/kg; Mild gastrointestinal side effects.
Affected Organisms
Humans and other mammals
Absorption Absorbed from the small intestine via an active transport mechanism requiring the presence of sodium.
External Links
Wikipedia
PDRhealth

REFERENCES