rac Zosuquidar-d5 Trihydrochloride

• Catalog No.: Z700872
• M. F.: C32H31F2N3O2
• M. W.: 527.6042464

SYNONYMS

• IUPAC name: 1-{4-[(2R,4S,11R)-3,3-difluorotetracyclo[10.4.0.0^2,^4.0^5,^1^0]hexadeca-1(12),5(10),6,8,13,15-hexaen-11-yl]piperazin-1-yl}-3-(quinolin-5-yloxy)(^2H₅)propan-2-ol
• IUPAC Traditional name: 1-{4-[(2R,4S,11R)-3,3-difluorotetracyclo[10.4.0.0^2,^4.0^5,^1^0]hexadeca-1(12),5(10),6,8,13,15-hexaen-11-yl]piperazin-1-yl}-3-(quinolin-5-yloxy)(^2H₅)propan-2-ol
• Synonyms: Zosuquidar-d5 Hydrochloride; RS 33295-198-d5; LY 335979-d5; rac-4-[(1aα,6α,10bα)-1,1-Difluoro-1,1a,6,10b-tetrahydrodibenzo[a,e]cyclopropa[c]cyclohepten-6-yl]-α-[(5-quinolinyloxy)methyl]-1-piperazineethanol-d5 Hydrochloride

DETAILS

Description (English)

Labelled Zosuquidar (Z700870). Multi-drug resistance (MDR) modulator; selective inhibitor of P-glycoprotein (P-gp). Antineoplastic adjunct (chemosensitizer).

REFERENCES

• Green, L.J., et al.: Biochem. Pharmacol., 61, 1393 (2001)
• Shepard, R.L., et al.: Int. J. Cancer, 103, 121 (2001)