Zomepirac Acyl-O-β-D-glucuronide

• Catalog No.: Z675010
• CAS Number: 75871-31-7
• M. F.: C21H22ClNO9
• M. W.: 467.85368
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: (2S,3S,4S,5R,6S)-6-({2-[5-(4-chlorobenzoyl)-1,4-dimethyl-1H-pyrrol-2-yl]acetyl}oxy)-3,4,5-trihydroxyoxane-2-carboxylic acid
• IUPAC Traditional name: (2S,3S,4S,5R,6S)-6-({2-[5-(4-chlorobenzoyl)-1,4-dimethylpyrrol-2-yl]acetyl}oxy)-3,4,5-trihydroxyoxane-2-carboxylic acid
• Synonyms: Zomepirac Acyl-1-O-β-D-glucuronide; Zomepirac Glucuronide; 1-[5-(4-Chlorobenzoyl)-1,4-dimethyl-1H-pyrrole-2-acetate] β-D-Glucopyranuronic Acid

DATABASE IDS

• CAS Number: 75871-31-7

PROPERTIES

• Apperance: Pale Yellow Solid
• Melting Point: >133°C (dec.)
• Solubility: Methanol
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

An unstable metabolite of the nonsteroidal anti-inflammatory drug (NSAID) Zomepirac (Z675000) that is capable of reacting with endogenous proteins to form potentially toxic covalent ZP-protein adducts.

REFERENCES

• King, A.R. et al.: J. Phamacol. Toxicol. Meth., 36, 131 (1996)
• Olsen, J. et al.: Chem. Res. Toxicol., 18, 1729 (1996)
• O’Neill, P.J. et al.: J. Clin. Pharmacol., 22, 470 (1996)