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Zofenopril Calcium Salt

Catalog No. Z587000 Name Toronto Research Chemicals
CAS Number 81938-43-4 Website http://www.trc-canada.com
M. F. C44H44CaN2O8S4 Telephone +1 (416) 665-9696
M. W. 897.16676 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage Refrigerator Chembase ID: 179645

SYNONYMS

IUPAC name
calcium bis((2R,4S)-1-[(2S)-3-(benzoylsulfanyl)-2-methylpropanoyl]-4-(phenylsulfanyl)pyrrolidine-2-carboxylate)
IUPAC Traditional name
calcium bis((2R,4S)-1-[(2S)-3-(benzoylsulfanyl)-2-methylpropanoyl]-4-(phenylsulfanyl)pyrrolidine-2-carboxylate)
Synonyms
Zofenil
Bifril-d5
[1(S),4(S)]-1-(3-Mercapto-2-methyl-1-oxopropyl)-4-phenyl-thio-L-proline-S-benzoyl Ester Calcium Salt

DATABASE IDS

CAS Number 81938-43-4

PROPERTIES

Certificate of Analysis Download
Apperance White to Off-White Solid
Melting Point 249-251°C
Solubility DMSO
Solubility Methanol (Sparingly)
MSDS Link Download
Storage Condition Refrigerator

DETAILS

Description (English)
Angiotensin-converting enzyme ACE inhibitor. A prodrug that is de-esterified to the active inhibitor, the sulfhydryl group containing metabolite, Zofenoprilat.

REFERENCES

  • Gorren, A., et al.: Biochem. J., 331, 801 (1998)
  • Subissi, A., et al.: Cardivascular Drug Reviews, 17, 2 (1998)
  • Marchand, C., et al.: Mol. Pharmacol., 64, 600 (1998)
  • Maurin, C., et al.: J. Med. Chem., 47, 5583 (1998)