Ximelagatran

• Catalog No.: X745000
• CAS Number: 192939-46-1
• M. F.: C24H35N5O5
• M. W.: 473.5652
• Storage: Hygroscopic, -20°C Freezer, Under inert atmosphere

SYNONYMS

• IUPAC name: ethyl 2-{[(1R)-1-cyclohexyl-2-[(2S)-2-({[4-(N-hydroxycarbamimidoyl)phenyl]methyl}carbamoyl)azetidin-1-yl]-2-oxoethyl]amino}acetate
• IUPAC Traditional name: ethyl 2-{[(1R)-1-cyclohexyl-2-[(2S)-2-({[4-(N-hydroxycarbamimidoyl)phenyl]methyl}carbamoyl)azetidin-1-yl]-2-oxoethyl]amino}acetate
• Synonyms: H 376/95; N-[(1R)-1-Cyclohexyl-2-[(2S)-2-[[[[4-[(hydroxyamino)iminomethyl]phenyl]methyl]amino]carbonyl]-1-azetidinyl]-2-oxoethyl]glycine Ethyl Ester; Exanta

DATABASE IDS

• CAS Number: 192939-46-1

PROPERTIES

• Apperance: Off-White Amorphous Solid
• Melting Point: 134-139°C
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: Hygroscopic, -20°C Freezer, Under inert atmosphere

DETAILS

Description (English)

An orally active direct thrombin inhibitor; prodrug of Melagatran. Antithrombotic.

REFERENCES

• Owens, P.K., et al.: J. Pharm. Biomed. Anal., 27, 587 (2002)
• Kalus, J.S., et al.: Expert Opin. Invest. Drugs, 13, 465 (2002)
• Boos, C.J., et al.: Eur. J. Int. Med., 16, 267 (2002)
• Cullberg, M., et al.: Clin. Pharmacol. Ther., 77, 279 (2002)