XAV 939

• Catalog No.: X744000
• CAS Number: 284028-89-3
• M. F.: C14H11F3N2OS
• M. W.: 312.3101496

SYNONYMS

• IUPAC name: 2-[4-(trifluoromethyl)phenyl]-1H,4H,5H,7H,8H-thiopyrano[4,3-d]pyrimidin-4-one
• IUPAC Traditional name: 2-[4-(trifluoromethyl)phenyl]-1H,5H,7H,8H-thiopyrano[4,3-d]pyrimidin-4-one
• Synonyms: NVP-XAV 939; 1,5,7,8-Tetrahydro-2-[4-(trifluoromethyl)phenyl]-4H-thiopyrano[4,3-d]pyrimidin-4-one

DATABASE IDS

• CAS Number: 284028-89-3

DETAILS

Description (English)

A tankyrase (TNKS) inhibitor that antagonizes Wnt signaling via stimulation of β-catenin degradation and stabilization of axin. XAV 939 inhibits proliferation of the μ-catenin-dependent colon carcinoma cell line DLD-1.

REFERENCES

• Huang, S. et al.: Nature, 461, 614 (2009)
• Wang, H. et al.: ACS Chem. Biol., 6, 192 (2009)
• Adles, M.E. et al.: Sci. Signal., 91, ec326 (2009)