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WYE 354-d3
Catalog No.	W950002	Name	Toronto Research Chemicals
CAS Number		Website	http://www.trc-canada.com
M. F.	C24H29N7O5	Telephone	+1 (416) 665-9696
M. W.	495.53096	Fax	+1 (416) 665-4439
Purity		Email	info@trc-canada.com
Storage		Chembase ID: 179590

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SYNONYMS

IUPAC name

methyl 4-[6-(4-{[(²H₃)methoxycarbonyl]amino}phenyl)-4-(morpholin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate

IUPAC Traditional name

methyl 4-[6-(4-{[(²H₃)methoxycarbonyl]amino}phenyl)-4-(morpholin-4-yl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate

Synonyms

4-[6-[4-[[(Methoxy-d3)carbonyl]amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic Acid Methyl Ester

WYE-354-d3

DATABASE IDS

PROPERTIES

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DETAILS

Description (English)

A labelled pyrazolopyrimidines derivative that is a potent and ATP-competitive mTOR inhibitor with much reduced activity against PI 3-Kα or PI 3-Kγ. WYE-354 is equally potent against mTORC1 and mTORC2 activities in HEK293 immune complex kinase assays usin

REFERENCES

Yu, K. et al.: Cancer Res., 69, 6232 (2009)
Zask, A. et al.: J. Med. Chem., 52, 5-13 (2009)
Dormind-Meuwly, A. et al.: Biochem. Biophys. Res. Comm., 407, 714 (2009)