WYE 354

• Catalog No.: W950000
• CAS Number: 1062169-56-5
• M. F.: C24H29N7O5
• M. W.: 495.53096

SYNONYMS

• IUPAC name: methyl 4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-(morpholin-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
• IUPAC Traditional name: methyl 4-(6-{4-[(methoxycarbonyl)amino]phenyl}-4-(morpholin-4-yl)pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate
• Synonyms: 4-[6-[4-[(Methoxycarbonyl)amino]phenyl]-4-(4-morpholinyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]-1-piperidinecarboxylic Acid Methyl Ester; WYE-354

DATABASE IDS

• CAS Number: 1062169-56-5

DETAILS

Description (English)

A pyrazolopyrimidines derivative that is a potent and ATP-competitive mTOR inhibitor with much reduced activity against PI 3-Kα or PI 3-Kγ. WYE-354 is equally potent against mTORC1 and mTORC2 activities in HEK293 immune complex kinase assays using S6K and

REFERENCES

• Yu, K. et al.: Cancer Res., 69, 6232 (2009)
• Zask, A. et al.: J. Med. Chem., 52, 5-13 (2009)
• Dormind-Meuwly, A. et al.: Biochem. Biophys. Res. Comm., 407, 714 (2009)