Ziconotide Polyacetate

• Catalog No.: Z385000
• CAS Number: 914454-03-8
• M. F.: C99H174N34O32S5
• M. W.: 2512.97446

SYNONYMS

• IUPAC name: (3S)-3-{[(2S,5S)-5-{2-[(1S)-1-{[(4S,7S)-7-{2-[(1S)-5-amino-1-{[(1R)-1-[({[(4S)-8-amino-1-{2-[(3S)-7-amino-2-oxoheptan-3-yl]hydrazin-1-yl}-2,3-dioxooctan-4-yl]carbamoyl}methyl)carbamoyl]ethyl]carbamoyl}pentyl]hydrazin-1-yl}-1-carbamimidamido-8-hydroxy-5,6-dioxooctan-4-yl]carbamoyl}-3-methylbutyl]hydrazin-1-yl}-1-(4-hydroxyphenyl)-7-(methylsulfanyl)-3,4-dioxoheptan-2-yl]carbamoyl}-3-[(2R)-2-[(2R)-2-[(2S,3R)-2-{2-[(2S)-2-[(2R)-2-[(2S)-2-[(2S)-2-{2-[(2S)-6-amino-2-[(2R)-2-hydrazinyl-3-sulfanylpropanamido]hexanamido]acetamido}-3-hydroxypropanamido]-5-carbamimidamidopentanamido]-3-sulfanylpropanamido]-3-hydroxypropanamido]acetamido}-3-hydroxybutanamido]-3-sulfanylpropanamido]-3-sulfanylpropanamido]propanoic acid; acetic acid
• IUPAC Traditional name: (3S)-3-{[(2S,5S)-5-{2-[(1S)-1-{[(4S,7S)-7-{2-[(1S)-5-amino-1-{[(1R)-1-[({[(4S)-8-amino-1-{2-[(3S)-7-amino-2-oxoheptan-3-yl]hydrazin-1-yl}-2,3-dioxooctan-4-yl]carbamoyl}methyl)carbamoyl]ethyl]carbamoyl}pentyl]hydrazin-1-yl}-1-carbamimidamido-8-hydroxy-5,6-dioxooctan-4-yl]carbamoyl}-3-methylbutyl]hydrazin-1-yl}-1-(4-hydroxyphenyl)-7-(methylsulfanyl)-3,4-dioxoheptan-2-yl]carbamoyl}-3-[(2R)-2-[(2R)-2-[(2S,3R)-2-{2-[(2S)-2-[(2R)-2-[(2S)-2-[(2S)-2-{2-[(2S)-6-amino-2-[(2R)-2-hydrazinyl-3-sulfanylpropanamido]hexanamido]acetamido}-3-hydroxypropanamido]-5-carbamimidamidopentanamido]-3-sulfanylpropanamido]-3-hydroxypropanamido]acetamido}-3-hydroxybutanamido]-3-sulfanylpropanamido]-3-sulfanylpropanamido]propanoic acid; acetic acid
• Synonyms: SNX 111; ω-Conotoxin M VIIA Acetate; ω-Conopeptide MVIIA Acetate; Prialt Acetate

DATABASE IDS

• CAS Number: 914454-03-8

DETAILS

Description (English)

Α selective antagonist of N-type voltage sensitive calcium channels (VSCC). Blocks neurotransmitter release by preventing depolarization-induced calcium influx. Used as a ligand for binding studies of voltage sensitive calcium channels. Analgesic; neuropr

REFERENCES

• Olivera, B.M., et al.: Biochemistry, 26, 2086 (1987)
• Barksdale, C.M., et al.: J. Clin. Ligand Assay, 19, 229 (1987)
• McGuire, D., et al.: J. Cardiovasc. Pharmacol., 30, 400 (1987)
• Staats, P.S., et al.: J. Am. Med. Assoc., 291, 63 (1987)