Voclosporin-d4

• Catalog No.: V678502
• M. F.: C30H55N3O4
• M. W.: 521.7754

SYNONYMS

• IUPAC name: (2S)-N-[(3S,13R,14R,16E)-12-(dimethylamino)-13-hydroxy-2,14-dimethyl-4,11-dioxo(17,18,19,19-^2H₄)nonadeca-16,18-dien-3-yl]-4-methyl-2-(methylamino)pentanamide
• IUPAC Traditional name: (2S)-N-[(3S,13R,14R,16E)-12-(dimethylamino)-13-hydroxy-2,14-dimethyl-4,11-dioxo(17,18,19,19-^2H₄)nonadeca-16,18-dien-3-yl]-4-methyl-2-(methylamino)pentanamide
• Synonyms: ISATX 247-d4; trans-ISA 247-d4; R 1524-d4; 6-[(2S,3R,4R,6E)-3-Hydroxy-4-methyl-2-(methylamino)-6,8-nonadienoic acid]cyclosporin A-d4

DETAILS

Description (English)

Labelled Voclosporin (V678500). A new agent for the treatment of noninfectious uveitis. Uveitis is an inflammatory, putative Th1-mediated autoimmune disease that affects various parts of the eye and is a leading cause of visual loss. Voclosporin, a ration

REFERENCES

• Aspeslet, L., et al.: Transplant Proc., 33, 1048 (2001)
• Cho, M., et al.: Arthritis Rheum., 46, 1202 (2001)
• Staatz, C., et al.: Clin. Pharmacokinet., 43, 623 (2001)