Voclosporin

• Catalog No.: V678500
• CAS Number: 515814-01-4
• M. F.: C32H57N3O5
• M. W.: 563.81208

SYNONYMS

• IUPAC name: (3E,6R,17S)-8-(dimethylamino)-6,18-dimethyl-17-[(2S)-4-methyl-2-(methylamino)pentanamido]-9,16-dioxononadeca-1,3-dien-7-yl acetate
• IUPAC Traditional name: (3E,6R,17S)-8-(dimethylamino)-6,18-dimethyl-17-[(2S)-4-methyl-2-(methylamino)pentanamido]-9,16-dioxononadeca-1,3-dien-7-yl acetate
• Synonyms: 6-[(2S,3R,4R,6E)-3-Hydroxy-4-methyl-2-(methylamino)-6,8-nonadienoic acid]cyclosporin A; trans-ISA 247; R 1524; ISATX 247

DATABASE IDS

• CAS Number: 515814-01-4

DETAILS

Description (English)

A new agent for the treatment of noninfectious uveitis. Uveitis is an inflammatory, putative Th1-mediated autoimmune disease that affects various parts of the eye and is a leading cause of visual loss. Voclosporin, a rationally designed novel calcineurin

REFERENCES

• Aspeslet, L., et al.: Transplant Proc., 33, 1048 (2001)
• Cho, M., et al.: Arthritis Rheum., 46, 1202 (2001)
• Staatz, C., et al.: Clin. Pharmacokinet., 43, 623 (2001)