Vinflunine Ditartrate

• Catalog No.: V314500
• CAS Number: 194468-36-5
• M. F.: C49H60F2N4O14
• M. W.: 967.0159064
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (2R,3R)-2,3-dihydroxybutanedioic acid methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-4-[(12S,14S)-16-(1,1-difluoroethyl)-12-(methoxycarbonyl)-1,10-diazatetracyclo[12.3.1.0^3,^1^1.0^4,^9]octadeca-3(11),4,6,8-tetraen-12-yl]-12-ethyl-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0^1,^9.0^2,^7.0^1^6,^1^9]nonadeca-2,4,6,13-tetraene-10-carboxylate
• IUPAC Traditional name: L(+)-tartaric acid methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-4-[(1R,12S,14S)-16-(1,1-difluoroethyl)-12-(methoxycarbonyl)-1,10-diazatetracyclo[12.3.1.0^3,^1^1.0^4,^9]octadeca-3(11),4,6,8-tetraen-12-yl]-12-ethyl-10-hydroxy-5-methoxy-8-methyl-8,16-diazapentacyclo[10.6.1.0^1,^9.0^2,^7.0^1^6,^1^9]nonadeca-2,4,6,13-tetraene-10-carboxylate
• Synonyms: 4'-Deoxy-20',20'-difluoro-5'-nor-vincaleukoblastine Ditartrate; (2β,3β,4β,5α,12β,19α)-4-(Acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methylaspidospermidine-3-carboxylic Acid Methyl Ester (2R,3R)-2,3-Dihydroxybutanedioate; BMS 710485; Javlor; 20',20'-Difluoro-3',4'-dihydrovinorelbine Ditartrate; F 12158

DATABASE IDS

• CAS Number: 194468-36-5

PROPERTIES

• Apperance: White Solid
• Melting Point: 244-246°C (dec)
• Solubility: DMSO
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

Vinflunine is a semisynthetic Vinca alkaloid with microtubule destabilizing and antiangiogenic activity. Vinflunine is a derivative of Vinorelbine. Vinflunine is used as an antineoplastic.

REFERENCES

• Kruczynski, A., et al.: Crit. Rev. Oncol. Hematol., 40, 159 (2001)
• Fabre, C., et al.: Biochem. Pharmacol., 64, 733 (2001)
• Bennouna, J. et al.: Ann. Oncol., 14, 630 (2001)
• Bennouna, J., et al.: Expert Opin. Invest. Drugs, 14, 1259 (2005).