Vincristine M1DISCONTINUED

• Catalog No.: V314240
• CAS Number: 910580-56-2
• M. F.: C45H54N4O10
• M. W.: 810.93106

SYNONYMS

• IUPAC name: methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-8-formyl-10-hydroxy-5-methoxy-4-[(5S,7S)-7-(methoxycarbonyl)-5-(2-oxobutyl)-1H,2H,3H,4H,5H,6H,7H,8H-azonino[5,4-b]indol-7-yl]-8,16-diazapentacyclo[10.6.1.0^1,^9.0^2,^7.0^1^6,^1^9]nonadeca-2(7),3,5,13-tetraene-10-carboxylate
• IUPAC Traditional name: methyl (1R,9R,10S,11R,12R,19R)-11-(acetyloxy)-12-ethyl-8-formyl-10-hydroxy-5-methoxy-4-[(5S,7S)-7-(methoxycarbonyl)-5-(2-oxobutyl)-1H,2H,3H,4H,5H,6H,8H-azonino[5,4-b]indol-7-yl]-8,16-diazapentacyclo[10.6.1.0^1,^9.0^2,^7.0^1^6,^1^9]nonadeca-2(7),3,5,13-tetraene-10-carboxylate
• Synonyms: (2β,3β,4β,5α,12R,19α)-4-(Acetyloxy)-6,7-didehydro-1-formyl-3-hydroxy-16-methoxy-15-[(5S,7S)-1,2,3,4,5,6,7,8-octahydro-7-(methoxycarbonyl)-5-(2-oxobutyl)azonino[5,4-b]indol-7-yl]aspidospermidine-3-carboxylic Acid Methyl Ester

DATABASE IDS

• CAS Number: 910580-56-2

DETAILS

Description (English)

The selective metabolite of Vincristine by CYP3A5.

REFERENCES

• Eap, C., et al.: Eur. J. Clin. Pharmacol., 60, 231 (2004)
• Zhou, X., et al.: Anticancer Res., 14, 1017 (2004)
• Dantzig, A., et al.: Cancer Res., 56, 4171 (2004)
• Brown, H., et al.: Drug Metab. Dispos., 35, 293 (2004)
• Dennison, J., et al.: J. Pharmacol. E