Verapamil Ethyl Methanethiosulfonate, Bromide

• Catalog No.: V125100
• CAS Number: 353270-25-4
• M. F.: C30H45BrN2O6S2
• M. W.: 673.7221
• Storage: Amber Vial, Refrigerator, Under Inert Atmosphere

SYNONYMS

• IUPAC name: [4-cyano-4-(3,4-dimethoxyphenyl)-4-(propan-2-yl)butyl][2-(3,4-dimethoxyphenyl)ethyl][2-(methanesulfonylsulfanyl)ethyl](methyl)azanium bromide
• IUPAC Traditional name: [4-cyano-4-(3,4-dimethoxyphenyl)-4-isopropylbutyl][2-(3,4-dimethoxyphenyl)ethyl][2-(methanesulfonylsulfanyl)ethyl](methyl)azanium bromide
• Synonyms: δ-Cyano-N-[2-(3,4-dimethoxyphenyl)ethyl]-3,4-dimethoxy-N-methyl-δ-(1-methylethyl)-N-[2-[(methylsulfonyl)thio]ethyl]benzenebutanaminium Bromide

DATABASE IDS

• CAS Number: 353270-25-4

PROPERTIES

• Apperance: White to Off-White Solid
• Melting Point: 105-110°C (foaming)
• Solubility: Dichloromethane
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: Amber Vial, Refrigerator, Under Inert Atmosphere

DETAILS

Description (English)

An analog of Verapamil. P Glycoprotein drug binding domain verapamil methanethiosulfonate. Useful for mapping the pore region of L-type calcium channels and Kv1.3 potassium channels.

REFERENCES

• Loo, T., et al.: J. Biol. Chem., 270, 843 (1995)
• Sharom, F., et al.: J. Membr. Biol., 160, 161 (1995)
• Kim, R., et al.: J. Clin. Invest., 101, 289 (1995)
• Lee, C., et al.: Biochemistry., 37, 3594 (1995)