Vemurafenib-d5

• Catalog No.: V118502
• M. F.: C23H18ClF2N3O3S
• M. W.: 489.9221264

SYNONYMS

• IUPAC name: N-{3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl}(2,2,3,3,3-^2H₅)propane-1-sulfonamide
• IUPAC Traditional name: N-{3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl}(2,2,3,3,3-^2H₅)propane-1-sulfonamide
• Synonyms: N-[3-[[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide-d5; Ro 51-85426-d5; PLX 4032-d5; RG 7204-d5

DETAILS

Description (English)

Labelled Vemurafeni, a selective BRAFV600E kinase inhibitor; an antitumor agent. Vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of t

REFERENCES

• Halaban, R. et al.: Pigm. Cell. Melonoma Res., 23, 190 (2010)
• Yang, H. et al.: Cancer Res., 70, 5518 (2010)
• Comin-Anduix, B. et al.: Clin. Cancer Res., 16, 6040 (2010)