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Vemurafenib

Catalog No. V118500 Name Toronto Research Chemicals
CAS Number 918504-65-1 Website http://www.trc-canada.com
M. F. C23H18ClF2N3O3S Telephone +1 (416) 665-9696
M. W. 489.9221264 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage Chembase ID: 72603

SYNONYMS

IUPAC name
N-{3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide
IUPAC Traditional name
vemurafenib
Synonyms
N-[3-[[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
RG 7204
PLX 4032
Ro 51-85426

DATABASE IDS

CAS Number 918504-65-1

PROPERTIES

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MSDS Link Download

DETAILS

Description (English)
Vemurafenib selective BRAFV600E kinase inhibitor; an antitumor agent. Vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of tumor cell l

REFERENCES

  • Halaban, R. et al.: Pigm. Cell. Melonoma Res., 23, 190 (2010)
  • Yang, H. et al.: Cancer Res., 70, 5518 (2010)
  • Comin-Anduix, B. et al.: Clin. Cancer Res., 16, 6040 (2010)