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VX 745 _Molecular_structure_CAS_209410-46-8)
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VX 745

Catalog No. V900500 Name Toronto Research Chemicals
CAS Number 209410-46-8 Website http://www.trc-canada.com
M. F. C19H9Cl2F2N3OS Telephone +1 (416) 665-9696
M. W. 436.2620664 Fax +1 (416) 665-4439
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SYNONYMS

IUPAC name
5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-b]pyridazin-6-one
IUPAC Traditional name
5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]pyrimido[1,6-b]pyridazin-6-one
Synonyms
5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-one

DATABASE IDS

CAS Number 209410-46-8

PROPERTIES

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DETAILS

Description (English)
VX 745 is a potent and selective inhibitor of p38α mitogen-activated protein (MAP) kinase. VX 745 is a potential anti-inflammatory agents. Studies suggest that VX 745 may be useful in the treatment of Werner syndrome.

REFERENCES

  • Haddad, J.J.: Curr. Opin. Invest. Drugs, 2, 1070 (2001)
  • Duffy, J.P. et al.: ACS Med. Chem. Lett., 2, 758 (2001)
  • Bagley, M.C. et al.: Pharmaceuticals, 3, 1842 (2001)