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URB754

Catalog No. U822000 Name Toronto Research Chemicals
CAS Number 86672-58-4 Website http://www.trc-canada.com
M. F. C16H14N2O2 Telephone +1 (416) 665-9696
M. W. 266.29456 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage Chembase ID: 179389

SYNONYMS

IUPAC name
6-methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazin-4-one
IUPAC Traditional name
6-methyl-2-[(4-methylphenyl)amino]-3,1-benzoxazin-4-one
Synonyms
6-Methyl-2-[(4-methylphenyl)amino]-4H-3,1-benzoxazine-4-one

DATABASE IDS

CAS Number 86672-58-4

PROPERTIES

Certificate of Analysis Download
Apperance Off-White Solid
Melting Point 201-203°C
Solubility DMSO
MSDS Link Download

DETAILS

Description (English)
URB754 is a potent, noncompetitive inhibitor of MGL, exhibiting an IC50 of 200 nM for the recombinant rat brain enzyme. It inhibits rat brain fatty acyl amide hydrolase (FAAH) less effectively with an IC50 of 32 μM and binds weakly to the rat CB1 receptor with an IC50 of 3.8 μM. It does not inhibit cyclooxygenase-1 (COX-1) or COX-2 at concentrations up to 100 μM. Inhibition of 2-AG hydrolysis is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management.

REFERENCES

  • Makara, J.K., et al.: Nat. Neurosci., 8, 1139 (2005)