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URB602

Catalog No. U821925 Name Toronto Research Chemicals
CAS Number 565460-15-3 Website http://www.trc-canada.com
M. F. C19H21NO2 Telephone +1 (416) 665-9696
M. W. 295.37554 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage Chembase ID: 130096

SYNONYMS

IUPAC name
cyclohexyl N-(3-phenylphenyl)carbamate
IUPAC Traditional name
cyclohexyl N-(3-phenylphenyl)carbamate
Synonyms
N-[1,1'-Biphenyl]-3-yl-carbamic Acid Cyclohexyl Ester
Biphenyl-3-yl Carbamic Acid, Cyclohexyl Ester

DATABASE IDS

CAS Number 565460-15-3

PROPERTIES

Certificate of Analysis Download
Apperance Off-White Solid
Melting Point 122-123°C
Solubility DMSO
MSDS Link Download

DETAILS

Description (English)
URB602 is a selective inhibitor of MGL, exhibiting an IC50 of 28 μM for the rat brain enzyme. It does not inhibit fatty acid amide hydrolase (FAAH) at concentrations up to 100 μM, or other lipid metabolizing enzymes such as diacylglycerol lipase or cyclooxygenase-2.5 6 Inhibition of 2-AG hydrolysis is associated with enhanced stress-induced analgesia and may represent a novel drug target in pain and stress management.

REFERENCES

  • Hohmann, A.G., et al.: Nature, 435, 1108 (2005)
  • Suplita, R.L., et al.: Neuropharmacol., Nov. 25 (epub), (2005)