UK-356618

• Catalog No.: U700585
• CAS Number: 230961-08-7
• M. F.: C34H43N3O4
• M. W.: 557.72292
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (2R)-N-[(1S)-2,2-dimethyl-1-{[(1R)-1-phenylethyl]carbamoyl}propyl]-N'-hydroxy-2-[3-(3-methyl-4-phenylphenyl)propyl]butanediamide
• IUPAC Traditional name: (2R)-N-[(1S)-2,2-dimethyl-1-{[(1R)-1-phenylethyl]carbamoyl}propyl]-N'-hydroxy-2-[3-(3-methyl-4-phenylphenyl)propyl]butanediamide
• Synonyms: PF-03890101; UK 356618; (2R)-N1-[(1S)-2,2-Dimethyl-1-[[[(1R)-1-phenylethyl]amino]carbonyl]propyl]-N4-hydroxy-2-[3-(2-methyl[1,1'-biphenyl]-4-yl)propyl]butanediamide

DATABASE IDS

• CAS Number: 230961-08-7

PROPERTIES

• Apperance: Beige Solid
• Melting Point: 95-105°C
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

Potent and selective inhibitor of matrix metalloprotease-3 (MMP-3) (IC50 = 5.9 nM). Displays selectivity over a range of MMPs (IC50 values are 73, 840, 1790, 1900 and 51000 for MMP-13, MMP-9, MMP-2, MMP-14 and MMP-1 respectively).

REFERENCES

• Fray, M.J. et al.: Bioorg. Med. Chem. Lett., 11, 571 (2001)
• Fray, M.J. et al.: J. Med. Chem., 46, 3514 (2001)