N-Trifluoroacetyl Deacetylcolchicine

• Catalog No.: T787025
• CAS Number: 26195-65-3
• M. F.: C22H22F3NO6
• M. W.: 453.4083896
• Storage: Refrigerator

SYNONYMS

• IUPAC name: 2,2,2-trifluoro-N-[(10S)-3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.0^2,^7]hexadeca-1(16),2(7),3,5,11,14-hexaen-10-yl]acetamide
• IUPAC Traditional name: 2,2,2-trifluoro-N-[(10S)-3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.0^2,^7]hexadeca-1(16),2(7),3,5,11,14-hexaen-10-yl]acetamide
• Synonyms: N-Deacetyl-N-(trifluoroacetyl)colchicine; 2,2,2-Trifluoro-N-[(7S)-5,6,7,9-tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamide; NSC 305987

DATABASE IDS

• CAS Number: 26195-65-3

PROPERTIES

• Apperance: Faintly Yellow Crystalline Powder
• Solubility: Chloromethane
• Solubility: Dichlormethane
• Solubility: DMSO
• Solubility: Methanol
• Storage Condition: Refrigerator

DETAILS

Description (English)

An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pa

REFERENCES

• Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992)
• Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1992)
• Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1992)
• Andreu, J.M., et al.: Biochemistry, 37, 8356 (1992)
• Jordan, A., et al.: Med. Res. Rev