(3S,6R,7S,8S,12Z,15S,16E)-1,3,15-Tris-{[tert-butyl(dimethyl)silyl]oxy}-7-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)heptadecyl-12,16-dien-5-one

• Catalog No.: T876675
• CAS Number: 193146-49-5
• M. F.: C45H87NO5SSi3
• M. W.: 838.49748

SYNONYMS

• IUPAC name: (7S,11S,12S,16Z,19S)-7-[(tert-butyldimethylsilyl)oxy]-11-hydroxy-2,2,3,3,8,8,10,12,16,21,21,22,22-tridecamethyl-19-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,20-dioxa-3,21-disilatricos-16-en-9-one
• IUPAC Traditional name: (7S,11S,12S,16Z,19S)-7-[(tert-butyldimethylsilyl)oxy]-11-hydroxy-2,2,3,3,8,8,10,12,16,21,21,22,22-tridecamethyl-19-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,20-dioxa-3,21-disilatricos-16-en-9-one

DATABASE IDS

• CAS Number: 193146-49-5

PROPERTIES

• Apperance: Colourless Oil
• Solubility: Acetone
• Solubility: Chloroform
• Solubility: Dichloromethane
• Solubility: Ethanol
• Solubility: Ethyl Acetate
• Solubility: Hexane
• Solubility: Methanol

DETAILS

Description (English)

An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical

REFERENCES

• Hoee, G., et al.: Pure Appl. Chem., 71, 11, 2019 (1999)
• Giannakakou, P., et al.: Proc. Natl. Acad. Sci. USA, 97, 2904 (2000)