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(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-Tris-{[tert-butyl(dimethyl)silyl]oxy}-1-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)heptadeca-12,16-dien-5-one_Molecular_structure_CAS_193146-53-1)
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(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-Tris-{[tert-butyl(dimethyl)silyl]oxy}-1-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)heptadeca-12,16-dien-5-one

Catalog No. T876625 Name Toronto Research Chemicals
CAS Number 193146-53-1 Website http://www.trc-canada.com
M. F. C45H87NO5SSi3 Telephone +1 (416) 665-9696
M. W. 838.49748 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage Chembase ID: 179025

SYNONYMS

IUPAC name
(5S,9S,10S,14Z,17S)-9-[(tert-butyldimethylsilyl)oxy]-5-(2-hydroxyethyl)-2,2,3,3,6,6,8,10,14,19,19,20,20-tridecamethyl-17-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,18-dioxa-3,19-disilahenicos-14-en-7-one
IUPAC Traditional name
(5S,9S,10S,14Z,17S)-9-[(tert-butyldimethylsilyl)oxy]-5-(2-hydroxyethyl)-2,2,3,3,6,6,8,10,14,19,19,20,20-tridecamethyl-17-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,18-dioxa-3,19-disilahenicos-14-en-7-one

DATABASE IDS

CAS Number 193146-53-1

PROPERTIES

Certificate of Analysis Download
Apperance Colourless Oil
Solubility Acetone
Solubility Dichloromethane
Solubility Ethanol
Solubility Ethyl Acetate
Solubility Methanol
MSDS Link Download

DETAILS

Description (English)
An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical

REFERENCES

  • Hoee, G., et al.: Pure Appl. Chem., 71, 11, 2019 (1999)
  • Giannakakou, P., et al.: Proc. Natl. Acad. Sci. USA, 97, 2904 (2000)