(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-Tris-{[tert-butyl(dimethyl)silyl]oxy}-1-hydroxy-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)heptadeca-12,16-dien-5-one

• Catalog No.: T876625
• CAS Number: 193146-53-1
• M. F.: C45H87NO5SSi3
• M. W.: 838.49748

SYNONYMS

• IUPAC name: (5S,9S,10S,14Z,17S)-9-[(tert-butyldimethylsilyl)oxy]-5-(2-hydroxyethyl)-2,2,3,3,6,6,8,10,14,19,19,20,20-tridecamethyl-17-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,18-dioxa-3,19-disilahenicos-14-en-7-one
• IUPAC Traditional name: (5S,9S,10S,14Z,17S)-9-[(tert-butyldimethylsilyl)oxy]-5-(2-hydroxyethyl)-2,2,3,3,6,6,8,10,14,19,19,20,20-tridecamethyl-17-[(1E)-1-(2-methyl-1,3-thiazol-4-yl)prop-1-en-2-yl]-4,18-dioxa-3,19-disilahenicos-14-en-7-one

DATABASE IDS

• CAS Number: 193146-53-1

PROPERTIES

• Apperance: Colourless Oil
• Solubility: Acetone
• Solubility: Dichloromethane
• Solubility: Ethanol
• Solubility: Ethyl Acetate
• Solubility: Methanol

DETAILS

Description (English)

An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical

REFERENCES

• Hoee, G., et al.: Pure Appl. Chem., 71, 11, 2019 (1999)
• Giannakakou, P., et al.: Proc. Natl. Acad. Sci. USA, 97, 2904 (2000)