Home > Compound List > Product Information
(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-Tris-{[tert-butyl(dimethyl)silyl]oxy}-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxo-heptadeca-12,16-dienoic Acid_Molecular_structure_CAS_193146-63-3)
Click picture or here to close

(3S,6R,7S,8S,12Z,15S,16E)-3,7,15-Tris-{[tert-butyl(dimethyl)silyl]oxy}-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxo-heptadeca-12,16-dienoic Acid

Catalog No. T876500 Name Toronto Research Chemicals
CAS Number 193146-63-3 Website http://www.trc-canada.com
M. F. C45H85NO6SSi3 Telephone +1 (416) 665-9696
M. W. 852.481 Fax +1 (416) 665-4439
Purity Email info@trc-canada.com
Storage Chembase ID: 179024

SYNONYMS

IUPAC name
(3S,7S,8S,12Z,15S,16E)-3,7,15-tris[(tert-butyldimethylsilyl)oxy]-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic acid
IUPAC Traditional name
(3S,7S,8S,12Z,15S,16E)-3,7,15-tris[(tert-butyldimethylsilyl)oxy]-4,4,6,8,12,16-hexamethyl-17-(2-methyl-1,3-thiazol-4-yl)-5-oxoheptadeca-12,16-dienoic acid

DATABASE IDS

CAS Number 193146-63-3

PROPERTIES

Certificate of Analysis Download
Apperance Off-White Sticky Foam
Solubility Acetone
Solubility Chloroform
Solubility Dichloromethane
Solubility Ethanol
Solubility Ethyl Acetate
MSDS Link Download

DETAILS

Description (English)
An intermediate in the synthesis of Epothilones. Epothilones are polyketide natural products that inhibit cancer cells by a mechanism similar to paclitaxel, and also are effective against paclitaxel-resistant tumours. Epothilone D is in phase I clinical

REFERENCES

  • Hoee, G., et al.: Pure Appl. Chem., 71, 11, 2019 (1999)
  • Giannakakou, P., et al.: Proc. Natl. Acad. Sci. USA, 97, 2904 (2000)