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Trabectedin

Catalog No. T703500 Name Toronto Research Chemicals
CAS Number 114899-77-3 Website http://www.trc-canada.com
M. F. C39H43N3O11S Telephone +1 (416) 665-9696
M. W. 761.83722 Fax +1 (416) 665-4439
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Storage Chembase ID: 178791

SYNONYMS

IUPAC name
(1R,12S,14R)-5,6',12-trihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxo-3',4'-dihydro-2'H-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.13,11.02,13.04,9.015,23.016,20]triacontane-26,1'-isoquinoline]-4(9),5,7,15,20,22-hexaen-22-yl acetate
IUPAC Traditional name
(1R,12S,14R)-5,6',12-trihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxo-3',4'-dihydro-2'H-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.13,11.02,13.04,9.015,23.016,20]triacontane-26,1'-isoquinoline]-4(9),5,7,15,20,22-hexaen-22-yl acetate
Synonyms
(1'R,6R,6aR,7R,13S,14S,16R)-5-(Acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethylspiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinolin]-19-one
Ecteinascidin 743
Et 743
NSC 648766
Yondelis

DATABASE IDS

CAS Number 114899-77-3

PROPERTIES

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DETAILS

Description (English)
A tetrahydroisoquinoline alkaloid with antitumor activity isolated from the Caribbean tunicate, Ecteinascidin turbinata. It is the first marine anticancer agent approved in the European Union for patients with soft tissue sarcoma (STS). Antineoplastic.

REFERENCES

  • Sakai, R., et al.: Proc. Natl. Acad. Sci., 89, 11456 (1992)
  • Aune, G., et al.: Anticancer Drugs, 13, 545 (1992)
  • Herrero, A., et al.: Cancer Res., 66, 8155 (1992)
  • Sugasawa, K., et al.: Carcinogenesis, 29, 455 (1992)