Trabectedin

• Catalog No.: T703500
• CAS Number: 114899-77-3
• M. F.: C39H43N3O11S
• M. W.: 761.83722

SYNONYMS

• IUPAC name: (1R,12S,14R)-5,6',12-trihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxo-3',4'-dihydro-2'H-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1^3,^1^1.0^2,^1^3.0^4,^9.0^1^5,^2^3.0^1^6,^2^0]triacontane-26,1'-isoquinoline]-4(9),5,7,15,20,22-hexaen-22-yl acetate
• IUPAC Traditional name: (1R,12S,14R)-5,6',12-trihydroxy-6,7'-dimethoxy-7,21,30-trimethyl-27-oxo-3',4'-dihydro-2'H-17,19,28-trioxa-24-thia-13,30-diazaspiro[heptacyclo[12.9.6.1^3,^1^1.0^2,^1^3.0^4,^9.0^1^5,^2^3.0^1^6,^2^0]triacontane-26,1'-isoquinoline]-4(9),5,7,15,20,22-hexaen-22-yl acetate
• Synonyms: (1'R,6R,6aR,7R,13S,14S,16R)-5-(Acetyloxy)-3',4',6,6a,7,13,14,16-octahydro-6',8,14-trihydroxy-7',9-dimethoxy-4,10,23-trimethylspiro[6,16-(epithiopropanoxymethano)-7,13-imino-12H-1,3-dioxolo[7,8]isoquino[3,2-b][3]benzazocine-20,1'(2'H)-isoquinolin]-19-one; Ecteinascidin 743; Et 743; NSC 648766; Yondelis

DATABASE IDS

• CAS Number: 114899-77-3

DETAILS

Description (English)

A tetrahydroisoquinoline alkaloid with antitumor activity isolated from the Caribbean tunicate, Ecteinascidin turbinata. It is the first marine anticancer agent approved in the European Union for patients with soft tissue sarcoma (STS). Antineoplastic.

REFERENCES

• Sakai, R., et al.: Proc. Natl. Acad. Sci., 89, 11456 (1992)
• Aune, G., et al.: Anticancer Drugs, 13, 545 (1992)
• Herrero, A., et al.: Cancer Res., 66, 8155 (1992)
• Sugasawa, K., et al.: Carcinogenesis, 29, 455 (1992)