Torin 1

• Catalog No.: T548700
• CAS Number: 1222998-36-8
• M. F.: C35H28F3N5O2
• M. W.: 607.6243296
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: 1-[4-(4-propanoylpiperazin-1-yl)-3-(trifluoromethyl)phenyl]-9-(quinolin-3-yl)-1H,2H-benzo[h]1,6-naphthyridin-2-one
• IUPAC Traditional name: 1-[4-(4-propanoylpiperazin-1-yl)-3-(trifluoromethyl)phenyl]-9-(quinolin-3-yl)benzo[h]1,6-naphthyridin-2-one
• Synonyms: 1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)benzo[h]-1,6-naphthyridin-2(1H)-one

DATABASE IDS

• CAS Number: 1222998-36-8

PROPERTIES

• Apperance: White Solid
• Melting Point: >223°C (dec.)
• Solubility: Chloroform
• Solubility: DMSO
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

Torin 1 is a potent and selective mTOR inhibitor (IC50 = 2 - 10 nM for mTORC1 and mTORC2). Displays 200-fold selectivity for mTOR over DNA-PK, ATM and hVps34.

REFERENCES

• Thoreen, et al.: J. Biol. Chem., 284, 8023 (2009)
• Liu, et al.: J. Med. Chem., 53, 7146 (2009)
• Peterson, et al.: Peterson, et al.: Cell, 146 408 (2009)