Topotecan-d6

• Catalog No.: T542502
• CAS Number: 1044904-10-0
• M. F.: C23H23N3O5
• M. W.: 421.44582
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (19S)-8-{[bis(^2H₃)methylamino]methyl}-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^2,^1^1.0^4,^9.0^1^5,^2^0]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione
• IUPAC Traditional name: (19S)-8-{[bis(^2H₃)methylamino]methyl}-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^2,^1^1.0^4,^9.0^1^5,^2^0]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione
• Synonyms: SKF-104864A-d6; Hycamtin-d6; NSC-609669-d6; (4S)-10-[(Dimethylamino-d6)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3’,4’,6-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione

DATABASE IDS

• CAS Number: 1044904-10-0

PROPERTIES

• Apperance: Yellow Solid
• Melting Point: >250°C(dec.)
• Solubility: Acidic Water
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

Labelled Topotecan (T542500). A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic.

REFERENCES

• Beijnen, J.H., et al.: J. Pharm. Biomed. Anal., 8, 789 (1990)
• BeiKingsburg, W.D., et al.: J. Med. Chem., 34, 98 (1990)
• Rowinsky, E.K., et al.: J. Clin. Oncol., 10, 647 (1990)