Topotecan Hydrochloride

• Catalog No.: T542500
• CAS Number: 119413-54-6
• M. F.: C23H24ClN3O5
• M. W.: 457.90676
• Storage: Refrigerator

SYNONYMS

• IUPAC name: (19S)-8-[(dimethylamino)methyl]-19-ethyl-7,19-dihydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0^2,^1^1.0^4,^9.0^1^5,^2^0]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaene-14,18-dione hydrochloride
• IUPAC Traditional name: topotecan hydrochloride
• Synonyms: (4S)-10-[(Dimethylamino)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3’,4’,6-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione Hydrochloride; Hycamtin; SKF-104864A; NSC-609669

DATABASE IDS

• CAS Number: 119413-54-6

PROPERTIES

• Apperance: Light Yellow-Green Solid
• Melting Point: 213-218°C (dec.)
• Solubility: DMSO
• Solubility: Methanol
• Solubility: Water
• Storage Condition: Refrigerator

DETAILS

Description (English)

A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic. Topotecan hydrochloride is a chemotherapy agent that is a topoisomerase 1 inhibitor.

REFERENCES

• Beijnen, J.H., et al.: J. Pharm. Biomed. Anal., 8, 789 (1990)
• BeiKingsburg, W.D., et al.: J. Med. Chem., 34, 98 (1990)
• Rowinsky, E.K., et al.: J. Clin. Oncol., 10, 647 (1990)