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(S)-(-)-Tolvaptan_Molecular_structure_CAS_331947-44-5)
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(S)-(-)-Tolvaptan

Catalog No. T536645 Name Toronto Research Chemicals
CAS Number 331947-44-5 Website http://www.trc-canada.com
M. F. C26H25ClN2O3 Telephone +1 (416) 665-9696
M. W. 448.9413 Fax +1 (416) 665-4439
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SYNONYMS

IUPAC name
N-{4-[(5S)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1H-1-benzazepine-1-carbonyl]-3-methylphenyl}-2-methylbenzamide
IUPAC Traditional name
N-{4-[(5S)-7-chloro-5-hydroxy-2,3,4,5-tetrahydro-1-benzazepine-1-carbonyl]-3-methylphenyl}-2-methylbenzamide
Synonyms
(S)-(-)-OPC 41061
N-[4-[[(5S)-7-Chloro-2,3,4,5-tetrahydro-5-hydroxy-1H-1-benzazepin-1-yl]carbonyl]-3-methylphenyl]-2-methylbenzamide

DATABASE IDS

CAS Number 331947-44-5

PROPERTIES

Certificate of Analysis Download
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DETAILS

Description (English)
An enantiomer of Tolvaptan. It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic

REFERENCES

  • Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000)
  • Udelson, J., et al.: Circulation, 104, 2417 (2000)
  • Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2000)
  • Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2000)