Tolafentrine

• Catalog No.: T531000
• CAS Number: 139308-65-9
• M. F.: C28H31N3O4S
• M. W.: 505.62844

SYNONYMS

• IUPAC name: N-{4-[(4aS,10bR)-8,9-dimethoxy-2-methyl-1H,2H,3H,4H,4aH,10bH-benzo[c]1,6-naphthyridin-6-yl]phenyl}-4-methylbenzene-1-sulfonamide
• IUPAC Traditional name: N-{4-[(4aS,10bR)-8,9-dimethoxy-2-methyl-1H,3H,4H,4aH,10bH-benzo[c]1,6-naphthyridin-6-yl]phenyl}-4-methylbenzenesulfonamide
• Synonyms: rel-(-)-N-[4-[(4aR,10bS)-1,2,3,4,4a,10b-Hexahydro-8,9-dimethoxy-2-methylbenzo[c][1,6]naphthyridin-6-yl]phenyl]-4-methylbenzenesulfonamide

DATABASE IDS

• CAS Number: 139308-65-9

DETAILS

Description (English)

A dual-selective phosphodiesterase 3/4 inhibitor used in chronic experimental pulmonary hypertension.

REFERENCES

• Huxtable, R., et al.: Pharmacol. Ther., 47, 371 (1990)
• Tanaka, K., et al.: Cancer Res., 55, 2927 (1990)
• Wagner, R., et al.: J. Pharmacol. Exp. Ther., 282, 1650 (1990)
• Cowan, K., et al.: Nat. Med., 6, 698 (1990)
• Shankavaram, U., et al.: J. Biol. Chem.,