ToceranibDiscontinued Pfizer Patent issues_Molecular_structure_CAS_356068-94-5)

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ToceranibDiscontinued Pfizer Patent issues
Catalog No.	T525500	Name	Toronto Research Chemicals
CAS Number	356068-94-5	Website	http://www.trc-canada.com
M. F.	C22H25FN4O2	Telephone	+1 (416) 665-9696
M. W.	396.4579032	Fax	+1 (416) 665-4439
Purity		Email	info@trc-canada.com
Storage		Chembase ID: 178686

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SYNONYMS

IUPAC name

5-{[(3Z)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-2,4-dimethyl-N-[2-(pyrrolidin-1-yl)ethyl]-1H-pyrrole-3-carboxamide

IUPAC Traditional name

5-{[(3Z)-5-fluoro-2-oxo-1H-indol-3-ylidene]methyl}-2,4-dimethyl-N-[2-(pyrrolidin-1-yl)ethyl]-1H-pyrrole-3-carboxamide

Synonyms

SU 11654

5-[(Z)-(5-Fluoro-1,2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-N-[2-(1-pyrrolidinyl)ethyl]-1H-pyrrole-3-carboxamide

PHA 291639

5-(5-Fluoro-2-oxo-1,2-dihydroindol-(3Z)-ylidenemethyl)-2,4-dimethyl-1H-pyrrole-3-carboxylic Acid (2-(Pyrrolidin-1-yl)ethyl)amide

DATABASE IDS

CAS Number

356068-94-5

PROPERTIES

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DETAILS

Description (English)

Toceranib is a multitargeted indolinone receptor tyrosine kinase (RTK) inhibitor. Toceranib exhibited activity against a variety of spontaneous malignancies in canine such as mast cell tumors, mixed mammary carcinomas, soft tissue sarcomas, and multiple m

REFERENCES

London, C.A. et al.: Clin. Cancer Res., 9, 2755 (2003)
Zavodovskaya, R. et al.: Am. J. vVt. Res., 67, 633 (2003)
Malone, E.K. et al.: Vet. Comp. Oncol., 8, 209 (2003)