Tipifarnib

• Catalog No.: T444880
• CAS Number: 192185-72-1
• M. F.: C27H22Cl2N4O
• M. W.: 489.39578
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: 6-[(R)-amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-1,2-dihydroquinolin-2-one
• IUPAC Traditional name: tipifarnib
• Synonyms: 6-[(R)-Amino(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methyl]-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone; Zarnestra; (R)-(+)-R 115777

DATABASE IDS

• CAS Number: 192185-72-1

PROPERTIES

• Apperance: Off-White to Pale Beige Solid
• Melting Point: 211-213°C (dec.)
• Solubility: Chloroform
• Solubility: Methanol
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A farnesyltransferase inhibitor. Sensitizes human multiple myeloma cell to proteasome inhibition by blocking degradation of bortezomib(B675700)-induced aggresomes. Also shown to inhibit the growth of myeloid leukemia cell lines and primary leukemia cells

REFERENCES

• David, E., et al.: Blood, 116, 5285 (2010)
• Nagai, T., et al.: Leukemia Res., 34, 1057 (2010)
• Hong, D., et al.: Clin. Cancer Res., 15, 7061 (2009)