Thiostrepton

• Catalog No.: T375150
• CAS Number: 1393-48-2
• M. F.: C72H85N19O18S5
• M. W.: 1664.8868
• Storage: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

SYNONYMS

• IUPAC name: 2-({2-[(1R,8S,11Z,18S,25S,26R,37R,40S,46S,53S,59S)-37-[(2S)-butan-2-yl]-18-[(2S,3R)-2,3-dihydroxybutan-2-yl]-11-ethylidene-59-hydroxy-8-[(1R)-1-hydroxyethyl]-60-[(1S)-1-hydroxyethyl]-26,40,46-trimethyl-43-methylidene-6,9,16,23,28,38,41,44,47-nonaoxo-27-oxa-3,13,20,56-tetrathia-7,10,17,24,30,36,39,42,45,48,52,58,62,63,64-pentadecaazanonacyclo[23.23.9.2^2^9,^3^2.1^2,^5.1^1^2,^1^5.1^1^9,^2^2.1^3^1,^3^5.1^5^4,^5^7.0^1,^5^3]tetrahexaconta-2(64),4,12(63),19(62),21,29(61),30,32(60),33,51,54,57-dodecaen-51-yl]-1,3-thiazol-4-yl}formamido)-N-(1-carbamoyleth-1-en-1-yl)prop-2-enamide
• IUPAC Traditional name: 2-({2-[(1R,8S,11Z,18S,25S,26R,37R,40S,46S,53S,59S)-37-[(2S)-butan-2-yl]-18-[(2S,3R)-2,3-dihydroxybutan-2-yl]-11-ethylidene-59-hydroxy-8-[(1R)-1-hydroxyethyl]-60-[(1S)-1-hydroxyethyl]-26,40,46-trimethyl-43-methylidene-6,9,16,23,28,38,41,44,47-nonaoxo-27-oxa-3,13,20,56-tetrathia-7,10,17,24,30,36,39,42,45,48,52,58,62,63,64-pentadecaazanonacyclo[23.23.9.2^2^9,^3^2.1^2,^5.1^1^2,^1^5.1^1^9,^2^2.1^3^1,^3^5.1^5^4,^5^7.0^1,^5^3]tetrahexaconta-2(64),4,12(63),19(62),21,29(61),30,32(60),33,51,54,57-dodecaen-51-yl]-1,3-thiazol-4-yl}formamido)-N-(1-carbamoyleth-1-en-1-yl)prop-2-enamide

DATABASE IDS

• CAS Number: 1393-48-2

PROPERTIES

• Apperance: Off-White Solid
• Melting Point: 248-257°C (dec.)
• Solubility: Chloroform
• Solubility: Acetic Acid
• Storage Condition: Hygroscopic, -20°C Freezer, Under Inert Atmosphere

DETAILS

Description (English)

Natural antibiotic derived from Streptomyces.

REFERENCES

• Starosta, A., et al.; Chem. Biol., 16, 1087 (2009)
• Gohil, V., et al.: Nat. Biotechnol., 28, 249 (2009)
• Kwok, J., et al.: Mol. Cancer Res., 8, 24 (2009)