Thapsigargin

• Catalog No.: T339250
• CAS Number: 67526-95-8
• M. F.: C34H50O12
• M. W.: 650.7536
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(acetyloxy)-4-(butanoyloxy)-3,3a-dihydroxy-3,6,9-trimethyl-8-{[(2Z)-2-methylbut-2-enoyl]oxy}-2-oxo-2H,3H,3aH,4H,5H,6H,6aH,7H,8H,9bH-azuleno[4,5-b]furan-7-yl octanoate
• IUPAC Traditional name: thapsigargin
• Synonyms: Octanoic Acid (3S,3aR,4S,6S,6aR,7S,8S,9bS)-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b- decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl Ester; Octanoic Acid [3S-[3α,3aβ,4α,6β,6aβ,7β,8α(Z),9bα]]-6-(Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[(2-methyl-1-oxo-2-butenyl)oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl Ester; (-)-Thapsigargin

DATABASE IDS

• CAS Number: 67526-95-8

PROPERTIES

• Apperance: Off-White Solid
• Melting Point: 84-90°C
• Solubility: Chloroform
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

A widely used inhibitor of the ubiquitous sarco-endoplasmic reticulum Ca(2+)-ATPases in mammalian cells. It acts as a potent, cell-permeable, IP3-independent intracellular calcium releaser that blocks the transient increase in intracellular Ca2+ induced b

REFERENCES

• Treiman, M. et al.: Trends Pharmacol. Sci., 19, 131 (1998)
• Korge, P. et al.: Eur. J. Biochem., 265, 273 (1998)
• Tsukamoto, A. Cell Biol. Int., 17, 969 (1998)
• Kutinova C.N. et al.: Cell Biol. Toxicol., 23, 337 (1998)