1,2,3,4-Tetrahydro Staurosporine

• Catalog No.: T295700
• CAS Number: 220038-19-7
• M. F.: C28H30N4O3
• M. W.: 470.5628
• Storage: -20°C Freezer

SYNONYMS

• IUPAC name: (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^2,^6.0^7,^2^8.0^8,^1^3.0^1^5,^1^9.0^2^0,^2^7.0^2^1,^2^6]nonacosa-8(13),14(28),15(19),20(27),21(26),22,24-heptaen-16-one
• IUPAC Traditional name: (2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-29-oxa-1,7,17-triazaoctacyclo[12.12.2.1^2,^6.0^7,^2^8.0^8,^1^3.0^1^5,^1^9.0^2^0,^2^7.0^2^1,^2^6]nonacosa-8(13),14(28),15(19),20(27),21(26),22,24-heptaen-16-one
• Synonyms: (9S,10R,11R,13R)-2,3,10,11,12,13,15,16,17,18-Decahydro-10-methoxy-9-methyl-11-(methylamino)-9,13-epoxy-1H,9H-diindolo[1,2,3-gh:3',2',1'-lm]pyrrolo[3,4-j][1,7]benzodiazonin-1-one; AFN 941

DATABASE IDS

• CAS Number: 220038-19-7

PROPERTIES

• Apperance: Off-White to Pale Yellow Solid
• Melting Point: >230°C (dec.)
• Solubility: Acetone
• Solubility: DMSO
• Storage Condition: -20°C Freezer

DETAILS

Description (English)

Staurosporine derivative for use as isoenzyme PKCα inhibitors and anticancer agents.

REFERENCES

• Pollack, V., et al.: J. Pharmacol. Exp. Ther., 291, 739 (1999)
• Barker, A., et al.: Bioorg. Med. Chem. Lett., 11, 1911 (1999)
• Brignola, P., et al.: J. Biol. Chem., 277, 1576 (1999)
• Amann, J., et al.: Cancer Res., 65, 226 (1999)
• Zhang, X., et al.: Cell,