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2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine_Molecular_structure_CAS_927871-76-9)
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2,3,4,5-Tetrahydro-7-methoxy-4-methyl-1,4-benzothiazepine

Catalog No. T293860 Name Toronto Research Chemicals
CAS Number 927871-76-9 Website http://www.trc-canada.com
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SYNONYMS

IUPAC name
7-methoxy-4-methyl-2,3,4,5-tetrahydro-1,4-benzothiazepine
IUPAC Traditional name
7-methoxy-4-methyl-3,5-dihydro-2H-1,4-benzothiazepine
Synonyms
S 107

DATABASE IDS

CAS Number 927871-76-9

PROPERTIES

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DETAILS

Description (English)
It is a benzothiazepine derivative that binds the RyR1 channel and enhances the binding affinity of Calstabin-1. By preventing the depletion of Calstabin-1 from the RyR1 complex, S 107 slows muscle fatique and reduces muscle damage in exercised mice. In a

REFERENCES

  • Li, A., et al.: Toxicology, 104, 1 (1995)
  • Balakin, K., et al.: Drug Metab. Dispos., 32, 1111 (1995)
  • Wehrens, X., et al.: Science, 304, 292 (1995)
  • Bellinger, A.M., et al.: Nature Med., 15, 325 (1995)