Tezosentan _Molecular_structure_CAS_180384-57-0)

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Tezosentan
Catalog No.	T321500	Name	Toronto Research Chemicals
CAS Number	180384-57-0	Website	http://www.trc-canada.com
M. F.	C27H27N9O6S	Telephone	+1 (416) 665-9696
M. W.	605.62498	Fax	+1 (416) 665-4439
Purity		Email	info@trc-canada.com
Storage		Chembase ID: 178317

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SYNONYMS

IUPAC name

N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(1H-1,2,3,4-tetrazol-5-yl)pyridin-4-yl]pyrimidin-4-yl]-5-(propan-2-yl)pyridine-2-sulfonamide

IUPAC Traditional name

N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(1H-1,2,3,4-tetrazol-5-yl)pyridin-4-yl]pyrimidin-4-yl]-5-isopropylpyridine-2-sulfonamide

Synonyms

N-[6-(2-Hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)-4-pyridinyl]-4-pyrimidinyl]-5-(1-methylethyl)-2-pyridinesulfonamide

DATABASE IDS

CAS Number

180384-57-0

PROPERTIES

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DETAILS

Description (English)

A potent dual endothelian (ETA/ETB) receptor antagonist optimized from Bosentan (B675900). It is used in the treatment of congestive heart failure.

REFERENCES

Clozel, M., et al.: J. Pharmacol. Exp. Ther., 290, 840 (1999)
Dingemanse, J., et al.: Br. J. Clin. Pharmacol., 53, 355 (1999)
Schalcher, C., et al.: Am. Heart J., 142, 340 (1999)